Purine nucleotide

Purine nucleotides are organic molecules composed of a purine base—adenine or guanine—attached to a pentose sugar and one or more phosphate groups. They are fundamental building blocks for nucleic acids such as DNA and RNA[5][8][9]. In addition to their genetic role, purine nucleotides like adenosine triphosphate (ATP) and guanosine triphosphate (GTP) serve as universal energy carriers in cells[4], participate in signal transduction pathways as cyclic AMP/GMP[3], regulate metabolic processes allosterically[2], and act as precursors for essential coenzymes such as NAD+, FAD, and CoA[3]. Disruption in their metabolism is implicated in diseases like gout and certain cancers. Note: "Purine nucleotide" is not itself a therapeutic target but rather a class of small molecules essential for cellular function. Enzymes involved in their synthesis/metabolism—such as xanthine oxidase or hypoxanthine/guanine phosphoribosyltransferase—are considered drug targets instead. Therefore, listing "purine nucleotides" directly as a molecular target is incorrect; the correct targets would be specific enzymes within the purinergic pathway[2].

Other names

Purine nucleotidespurines (when referring to the nucleotide form)adenine nucleotideguanine nucleotide

Inhibition of purine synthesis or metabolism by structural analogs or enzyme inhibitors[2]