Target intelligence / Profile preview

Purine Nucleotide Cycle (PNC)

Target: PNC
Molecular classification: Metabolic Pathway

Overview

The purine nucleotide cycle (PNC) is a metabolic pathway that interconverts adenine nucleotides, producing fumarate for TCA cycle anaplerosis and releasing ammonia. It is essential for rapid ATP regeneration during high-energy demand states.

Biological functions

Regulation of adenine nucleotide levelsTCA cycle anaplerosis (fumarate production)Ammonia productionATP regeneration

Disease associations

Exercise intolerance (related to AMP deaminase deficiency)Psychomotor retardation (related to adenylosuccinate lyase deficiency)Autism (related to adenylosuccinate lyase deficiency)

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