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Purine P2X3 Receptor (None)
- Target
- None
- Molecular classification
- Ligand-gated ion channel, Purinoceptor
01
Overview
The Purine P2X3 receptor (P2X purinoceptor 3) is a ligand-gated ion channel belonging to the family of purinergic receptors for ATP. It plays a key role in sensory neurotransmission, particularly in pain signaling and other physiological processes. It is expressed predominantly at central/peripheral terminals and cell bodies of small-diameter sensory neurons. Selective antagonism of the human P2X3 receptor is being explored for novel analgesics targeting chronic pain conditions and disorders involving abnormal urinary bladder function.
- Other names
- P2X purinoceptor 3Purinergic receptor P2X 3P2X3P2RX3P2X purinoceptor ligand-gated ion channel 3
02
Mechanism of action
Selective antagonism of P2X3 receptor
03
Biological functions
NociceptionSensory neurotransmissionBladder reflexesImmune modulationPlatelet aggregationApoptosisNeuronal-glial interactionPain signalingPeripheral nervous systemCentral nervous system
04
Disease associations
Chronic painAbnormal urinary bladder function
05
Interacting drugs
ATP
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