Purinergic P2 Receptor (P2 receptor)

Purinergic P2 receptors are a family of cell surface receptors activated by extracellular nucleotides, primarily ATP. They are divided into two main subtypes: P2X receptors (ligand-gated ion channels) and P2Y receptors (G protein-coupled receptors). Expressed on various cell types, they regulate immune responses, neuronal signaling, vascular function, and mechanotransduction. Dysregulation is implicated in chronic inflammation, neurodegenerative disorders, and thrombosis, making them therapeutic targets.

Other names

P2 receptorsPurinoceptorsATP receptors

Various, including receptor antagonism and ion channel blockade. Examples include clopidogrel inhibiting ADP-induced platelet aggregation via P2Y12 blockade, and specific inhibitors targeting neuroimmune functions mediated by ionotropic or metabotropic forms.