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Target intelligence / Profile preview
Purinergic P2Y12 receptor (P2Y12)
- Target
- P2Y12
- Molecular classification
- G protein-coupled receptor, GPCR, G-protein coupled receptor 1 family
01
Overview
The purinergic P2Y12 receptor (P2Y12) is a G protein-coupled receptor that primarily functions as a chemoreceptor for adenosine diphosphate (ADP). It plays a crucial role in platelet aggregation and microglial function in the central nervous system. Targeting P2Y12 with antagonists like clopidogrel is a common strategy to prevent thromboembolic events.
- Other names
- Purinergic receptor P2RY12Purinoceptor 12ADP-glucose receptorG-protein coupled receptor SP1999Gi-coupled ADP receptor HORK3
02
Mechanism of action
Irreversible antagonist of P2Y12 receptor, inhibiting ADP-induced platelet aggregation
03
Biological functions
Platelet aggregationMicroglial function in CNSChemoreceptor for ADPSignal transductionHemostasisPlatelet activationPlatelet recruitmentNeuroprotection
04
Disease associations
Thromboembolic eventsMyocardial infarctionStrokeEpilepsyAcute myocardial infarctionBleeding disordersPlatelet-type Bleeding Disorder 8Cardiovascular disease
05
Safety considerations
Increased bleeding riskAltered risk for epilepsyAltered risk for acute myocardial infarctionAltered risk for bleeding disorders
06
Interacting drugs
Clopidogrel
07
Biomarkers
Genetic polymorphisms in P2RY12 gene
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