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Target intelligence / Profile preview
Purinergic receptor P2X 1 (P2RX1)
- Target
- P2RX1
- Molecular classification
- Ligand-gated ion channel, Purinergic receptor
01
Overview
The purinergic receptor P2X1 (P2RX1) is a ligand-gated ion channel activated by extracellular ATP. It plays a crucial role in various physiological processes, including smooth muscle contraction, platelet activation, and immune responses. Its involvement in multiple systems makes it a potential therapeutic target for conditions like male infertility, hypertension, and thrombosis.
- Other names
- ATP receptorP2X1 receptor
02
Mechanism of action
Ligand-gated ion channel activation/inhibition
03
Biological functions
Synaptic transmissionVasoconstrictionPlatelet activationHematopoietic stem/progenitor cell regulationEosinophil adhesion
04
Disease associations
Male infertilityAsthmaHypertensionThrombosis
05
Safety considerations
Potential for off-target effects due to widespread expressionCardiovascular effects related to vasoconstriction
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