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Target intelligence / Profile preview
Purinergic Receptor P2X Ligand-Gated Ion Channel 7 (P2X7)
- Target
- P2X7
- Molecular classification
- Ion channel, Ligand-gated ion channel, Purinergic receptor, P2X receptor
01
Overview
The P2X purinoceptor 7 (P2X7 receptor) is a ligand-gated ion channel activated by high concentrations of extracellular ATP. It forms a homo- or hetero-trimeric channel and allows cation influx, leading to downstream signaling events such as NLRP3 inflammasome activation and IL-1β release. Dysregulation of P2X7 has been implicated in various diseases, including chronic inflammatory diseases, neuropathic pain, neurodegenerative disorders, and cancer.
- Other names
- Purinergic ReceptorP2Z Receptor
02
Mechanism of action
Ligand-gated ion channel activation leading to cation influx and pore formation, triggering downstream signaling cascades such as NLRP3 inflammasome activation and IL-1β release.
03
Biological functions
Ion transportSignal transductionInflammationApoptosisCell deathPattern recognition receptor
04
Disease associations
Chronic inflammatory diseasesNeuropathic painNeurodegenerative disordersCancerInfectious disease
05
Safety considerations
Potential for excessive inflammation due to NLRP3 inflammasome activation.Possible contribution to apoptotic/necrotic cell death.Dysregulation or genetic variation can lead to various diseases.Off-target effects due to widespread expression.
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