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Target intelligence / Profile preview
Purinergic Receptor P2X3 (P2RX3)
- Target
- P2RX3
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor
01
Overview
The purinergic receptor P2X3 (P2RX3) is a ligand-gated ion channel activated by extracellular ATP. It is primarily expressed in sensory neurons and mediates fast synaptic transmission of pain signals. It is involved in pain responses, hyperalgesia, allodynia, urinary bladder reflexes, and auditory neuron maturation. Selective antagonism of this receptor has therapeutic potential for treating chronic pain conditions and disorders involving abnormal urine storage or cough reflexes.
- Other names
- Purinergic receptor P2X purinoceptor 3Purinergic receptor P2X ligand-gated ion channel 3
02
Mechanism of action
Ligand-gated ion channel activation/inhibition
03
Biological functions
Mediates nociceptive signalingFast synaptic transmissionUrinary bladder reflexesPlatelet aggregationMacrophage activationApoptosis regulationNeuronal–glial interactionsAuditory neuron maturation
04
Disease associations
Chronic painNeuropathic painOveractive bladderChronic coughTemporal lobe epilepsyHyperalgesiaAllodynia
05
Interacting drugs
αβ-meATP
3 more in the full profile.
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