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Target intelligence / Profile preview
Purinergic Receptor P2X7 (P2X7R)
- Target
- P2X7R
- Molecular classification
- Ligand-gated ion channel, P2X receptor, Purinoceptor
01
Overview
The purinergic P2X7 receptor (P2X7R) is a ligand-gated cation channel activated by extracellular ATP. It plays a critical role in inflammation, cancer, neurological disorders, and cardiovascular diseases. Activation of P2X7R leads to ion influx, NLRP3 inflammasome activation, and potentially cell death. Its expression is widespread, particularly in immune cells, the nervous system, and cancer cells, making it a therapeutic target for various conditions.
- Other names
- P2X7 receptorP2X7Purinergic P2X7 receptor
02
Mechanism of action
Ligand-gated ion channel activation; NLRP3 inflammasome activation; Induction of cell death
03
Biological functions
Ion channel activitySignal transductionInflammationCell deathImmune responseNLRP3 inflammasome activation
04
Disease associations
InflammationCancerNeurological disordersCardiovascular diseaseEpilepsyAtherosclerosisMyocardial ischemic injuryHeart failureHypertension
05
Safety considerations
Potential for both pro-tumor and anti-tumor effects in cancerRegulation of inflammationPotential for pyroptosis (inflammatory cell death)
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