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Target intelligence / Profile preview
Purinergic Receptor P2Y₂ (P2Y₂R)
- Target
- P2Y₂R
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The P2Y₂ receptor is a G protein-coupled receptor activated by ATP and UTP. It is widely expressed and plays roles in adipogenesis, inflammation, cancer progression, and other diseases. It signals through Gαq and integrin-mediated pathways. Selective antagonists are under development as potential therapeutics.
- Other names
- P2RY2HP2UP2RU1P2UP2U1P2URP2Y₂RPurinergic receptor P2Y₂
02
Mechanism of action
Activation by ATP/UTP leads to Gαq-mediated activation of PLC, IP₃ production, and intracellular calcium release. Also activates small GTPases (Rho, Rac, Cdc42) via integrin interactions.
03
Biological functions
Signal transductionCell proliferationCell migrationCell differentiationInflammation regulationMetabolic regulationCalcium signaling
04
Disease associations
ObesityMetabolic syndromeInflammationCancerFibrosisAutoimmune disorders
05
Safety considerations
Limited availability of selective antagonists with good drug-like properties.Potential for broad effects due to widespread tissue expression and involvement in multiple signaling pathways.
06
Interacting drugs
ATP
2 more in the full profile.
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