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Purinergic receptor P2Y, G-protein coupled, 12 (P2Y12 receptor)
- Target
- P2Y12 receptor
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR
01
Overview
The P2Y12 receptor is a G protein-coupled receptor primarily expressed on platelets, where it plays a crucial role in ADP-mediated platelet aggregation and activation. It is a key target for antiplatelet therapies used to prevent and treat arterial thrombosis.
- Other names
- P2RY12ADP receptor P2Y12
02
Mechanism of action
Inhibits adenyl cyclase, leading to decreased intracellular cAMP levels, reduced VASP phosphorylation, and increased platelet aggregation.
03
Biological functions
Platelet aggregationPlatelet activationSignal transductionInflammation modulation
04
Disease associations
ThrombosisCardiovascular diseaseBleeding disordersInflammation
05
Safety considerations
Bleeding riskDrug resistanceIndividual variability in drug response
06
Interacting drugs
Clopidogrel
4 more in the full profile.
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