Purinergic Receptor P2Y Family (P2Y)

The purinergic receptor P2Y family comprises a group of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides, including ATP, ADP, UTP, UDP, and UDP-glucose. They play key roles in purinergic signaling, regulating diverse physiological processes through different subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14) that vary in ligand specificity, G protein coupling, tissue distribution, and function. These receptors are involved in platelet aggregation, neuronal activity modulation, microglial function, inflammation regulation, and potentially neurodegenerative diseases. Drugs targeting specific P2Y subtypes, such as antiplatelet agents targeting P2Y12, have been developed for clinical use.

Other names

P2Y receptorsPurinergic P2Y receptorsP2YR

Agonist or antagonist at specific P2Y receptor subtypes, modulating downstream signaling pathways such as PLC activation, IP3/DAG production, Ca2+ release, adenylyl cyclase inhibition, and cAMP reduction.