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Target intelligence / Profile preview
Purinergic Receptor P2Y1
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The purinergic receptor P2Y1 (P2RY1) is a G protein-coupled receptor that functions as a receptor for extracellular nucleotides, primarily ADP. It plays a critical role in platelet activation and aggregation, insulin secretion, and vasodilation. It is implicated in several diseases, including thrombosis, renal cell carcinoma, type 2 diabetes, and neurological disorders.
- Other names
- P2RY1P2Y1 receptorADP receptor P2Y1
02
Mechanism of action
Gq protein activation, phospholipase C (PLC) stimulation, IP3 and DAG generation, intracellular Ca2+ increase
03
Biological functions
Signal transductionPlatelet aggregationVasodilationInsulin secretionCalcium signaling
04
Disease associations
ThrombosisRenal cell carcinomaType 2 diabetesNeurological disordersAlzheimer's diseaseEpilepsy
05
Safety considerations
Context-dependent effects of inhibitorsPotential for bleeding complications with anti-thrombotic therapy
06
Interacting drugs
ADP
3 more in the full profile.
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