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Target intelligence / Profile preview
Purinergic Receptor P2Y1 Subtype (P2RY1)
- Target
- P2RY1
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Purinergic receptor
01
Overview
The purinergic receptor P2Y₁ plays a central role in platelet activation/aggregation through its response to extracellular nucleotides like ADP, making it a significant target for antithrombotic therapies. Its broader physiological roles are still being elucidated but likely extend into vascular biology and possibly neurobiology due to widespread tissue distribution.
- Other names
- P2Y1 receptorP2Y₁ receptorP2RY1ATP receptorplatelet ADP receptorP2Y ATP receptor 1
02
Mechanism of action
Agonist binding leads to activation of phospholipase C and mobilization of intracellular calcium, resulting in platelet shape change and aggregation. Antagonists block ADP binding and subsequent activation.
03
Biological functions
Signal transductionPlatelet aggregationCalcium mobilizationVascular tone regulationImmune response
04
Disease associations
ThrombosisRenal cell carcinoma
05
Safety considerations
Increased bleeding risk with antagonists due to inhibition of platelet aggregation.
06
Interacting drugs
ADP
1 more in the full profile.
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