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Target intelligence / Profile preview
Purinoceptor P2Y12 (P2Y12)
- Target
- P2Y12
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Rhodopsin-like GPCR
01
Overview
The P2Y12 purinoceptor is a G protein-coupled receptor primarily functioning as a chemoreceptor for ADP, mediating platelet aggregation. It is a key regulator of hemostasis and thrombosis and is expressed on platelets and microglia. It is a target for antiplatelet therapy in thromboembolic diseases. Genetic polymorphisms are associated with cardiovascular and neurological conditions.
- Other names
- SP1999P2Y(ADP)ADPG-RNucleotide P2Y(12) receptor
02
Mechanism of action
Antagonism of P2Y12 receptor, inhibiting ADP-mediated platelet activation and aggregation
03
Biological functions
Platelet aggregation via ADP signalingSignal transductionHemostasisNeuroprotectionMicroglial cell function
04
Disease associations
Thromboembolic diseasesMyocardial infarctionStrokeEpilepsyAcute myocardial infarctionInflammation (e.g., allergic asthma)Cardiovascular disease
05
Safety considerations
Increased bleeding riskVaried drug effectiveness (e.g., Clopidogrel)Potential neurological implications
06
Interacting drugs
Clopidogrel
2 more in the full profile.
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