Putative E3 ubiquitin-protein ligase UNKL (UNKL)

Putative E3 ubiquitin-protein ligase UNKL is a zinc finger protein classified within the RING finger family, encoded by the UNKL gene (also referred to as C16orf28, ZC3H5L, ZC3HDC5L, among other aliases)[1]. It is thought to function in Rac signaling pathways and mediates protein-protein interactions by binding to the Brg/Brm-associated factor 60b, promoting its ubiquitination—a process essential for protein turnover and regulation[1]. Multiple transcript variants arise due to alternative splicing. The protein features canonical zinc finger domains, notably the RING finger and CCCH motifs, commonly known for roles in nucleic acid binding and protein regulation. While not directly linked to major disease categories in curated databases, UNKL may be implicated in cell-regulatory processes relevant to disease progression, though specifics remain unclear[1]. No direct pharmacological agents, mechanisms of action, biomarkers, or safety concerns have been reported for UNKL as of current literature[1].

Other names

C16orf28ZC3H5LZC3HDC5LFLJ23360RING finger protein unkempt-likeZinc finger CCCH domain-containing protein 5-likeUnkempt family zinc finger-likeUnkempt homolog-like