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Putative keratin-associated protein 20-4 (KRTAP20-4)
- Target
- KRTAP20-4
- Molecular classification
- Other (Keratin-associated protein, high glycine-tyrosine family)
01
Overview
Putative keratin-associated protein 20-4 (KRTAP20-4) belongs to the high glycine-tyrosine (HGT) keratin-associated protein (KAP) family, which forms part of the matrix that embeds hair keratin intermediate filaments within the hair cortex[3][2]. KRTAP20 subfamily proteins are characterized by a high content of glycine and tyrosine residues, contributing to their structural role in hair fiber morphology[2]. The primary function of these proteins is to help build the rigid yet flexible structure of the hair by supporting and crosslinking keratin intermediate filaments[3][2]. This gene is mostly studied for its influence on traits of animal fibers, such as wool diameter and yield in livestock. There is currently no evidence to support KRTAP20-4 as a therapeutic target, nor is it implicated in specific diseases or associated with any drugs[3][2][1].
- Other names
- KRTAP20-4KAP20.4putative keratin-associated protein 20-4
02
Biological functions
Hair cortex structureHair fiber matrix formation
03
Disease associations
Other (no established direct disease associations; roles in hair and wool fiber properties)
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