Putative protein N-methyltransferase FAM86B1 (FAM86B1)

Putative protein N-methyltransferase FAM86B1 is a human enzyme encoded by the FAM86B1 gene (located at chromosome 8p23.1), classified as a putative protein-lysine N-methyltransferase[5][2][4]. The protein is predicted to catalyze methylation of lysine residues, but unlike its close paralog FAM86A, its endogenous substrate remains unknown[1][4][5]. FAM86B1 contains both a FAM86 domain and an AdoMet-MTase (S-adenosylmethionine–dependent methyltransferase) domain, and is expressed in various tissues, with particularly strong expression in brain and pituitary gland[3]. FAM86B1 is essential in humans and has been implicated in cancer (e.g., expression changes linked to prognosis in glioblastoma, bladder, and uterine cancers), infection (e.g., response to respiratory syncytial virus and enterovirus-71), and inflammation (e.g., rheumatoid arthritis and ischemic conditions)[3][4]. FAM86B1 undergoes post-translational modifications such as phosphorylation and ubiquitination[4]. No approved drugs, therapeutic targeting strategies, or definitive substrates have been established for this protein as of now[1][5].

Other names

FAM86B1family with sequence similarity 86 member B1MGC16279protein FAM86B1putative protein N-methyltransferase FAM86B1