Putative TLX1 neighbor protein (TLX1NB)

Putative TLX1 neighbor protein (TLX1NB) is a gene annotated as a long non-coding RNA (lncRNA), found adjacent to the TLX1 gene on chromosome 10q24. It is oriented head-to-head with TLX1, sharing a common bidirectional promoter with robust activity. The transcript is predicted to encode a small protein of 13.4 kDa, but has no significant similarity to known proteins and lacks evidence of protein-coding function[2][9]. TLX1NB is transcriptionally co-activated in leukemic cells overexpressing TLX1, suggesting a potential functional link in leukemogenesis, but its precise biological role remains unresolved[2][8]. TLX1NB is not classified as a therapeutic target or member of traditional receptor/enzyme/transporter families; it is best considered within the category of lncRNAs involved in transcriptional regulation and possibly cancer biology[1][2][5][9].

Other names

APT-B7TD1TDITLX1 divergent gene proteinTLX1NBputative TLX1 neighbor proteinTLX1 divergent