Putative uncharacterized protein LOC400499

Putative uncharacterized protein LOC400499 is a predicted protein-coding gene localized to chromosome 16p13.13 in humans[1][3][7]. It is annotated in several databases (NCBI Gene ID: 400499, Ensembl: ENSG00000188897)[3][7]. The protein lacks experimentally verified function but is suggested to be involved in epithelial barrier maintenance and immune processes[1]. Gene Ontology and Panther annotations associate it with scaffold/adaptor protein activity and regulation of cytokine production[2][4], as well as possible lipid transporter activity[3]. Bioinformatics analyses and domain predictions suggest that the protein contains domains of unknown function (e.g., DUF3150, DUF2799), with possible cytoplasmic localization[5]. Some studies suggest that it may interact with drugs such as flumequine, oxytetracycline, and florfenicol based on in silico docking studies in bacterial homologs, but such pharmacological relevance is unconfirmed in humans[5]. There is no evidence of established therapeutic targeting, biomarker use, disease association, or safety profile in humans. The gene remains largely uncharacterized, and its functional, structural, and disease relevance is unclear at this time, making it generally inappropriate to consider it a validated therapeutic target.

Other names

novel lipoprotein amino terminal region containing proteinLOC400499ENSG00000188897putative uncharacterized protein LOC400499