Target intelligence / Profile preview

Puumala Virus Glycoprotein Gn-Gc (Gn-Gc)

Target: Gn-Gc
Molecular classification: Viral Glycoprotein, Membrane protein, Fusion protein (Gc), Attachment protein (Gn)

Overview

The Puumala virus (PUUV) Gn-Gc glycoprotein complex, consisting of the Gn and Gc glycoproteins, is essential for viral entry into host cells. Gn mediates attachment to host cell receptors, while Gc facilitates membrane fusion upon endocytosis and exposure to low pH. The Gn-Gc complex is a major target for neutralizing antibodies and a key determinant of PUUV pathogenicity. Targeting these glycoproteins is a viable strategy for antiviral development.

Other names: PUUV Gn-GcPuumala virus envelope glycoproteinsGnGc

Mechanism of action

Inhibition of viral entry by blocking attachment (Gn) or fusion (Gc)

Biological functions

Viral attachmentMembrane fusionViral entryVirion assemblyImmune evasion

Disease associations

Nephropathia epidemica (NE)Hemorrhagic fever with renal syndrome (HFRS)Puumala virus infection

Safety considerations

Potential for off-target effects due to structural similarity to host proteinsDevelopment of resistance to antiviral therapies

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