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Target intelligence / Profile preview
PVR Related Immunoglobulin Domain Containing (PVRIG)
- Target
- PVRIG
- Molecular classification
- Type I transmembrane protein, Immunoglobulin superfamily receptor, Immune checkpoint receptor
01
Overview
PVRIG (PVR Related Immunoglobulin Domain Containing), also known as CD112R (CD112 receptor), is an inhibitory immune checkpoint receptor primarily expressed on T cells and NK cells. It interacts with Nectin-2/CD112 (PVRL2), leading to suppression of T-cell function and regulation of NK cell activity. PVRIG is a target for cancer immunotherapy, and blocking its interaction with PVRL2 can enhance anti-tumor immune responses, potentially synergizing with other immunotherapies such as PD-L1 blockade.
- Other names
- CD112RCD112 receptor
02
Mechanism of action
Blocks PVRIG-PVRL2 interaction, enhances T-cell and NK cell-mediated anti-tumor responses
03
Biological functions
Immune response regulationT cell inhibitionNK cell regulationReceptor signalingNegative regulation of T cell receptor signaling pathwayPhosphatase binding
04
Disease associations
Cancer
05
Interacting drugs
COM701
2 more in the full profile.
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