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Target intelligence / Profile preview
PWWP domain-containing protein 2B (PWWP2B)
- Target
- PWWP2B
- Molecular classification
- Chromatin-binding protein, Histone modification adapter protein, Nuclear protein, DNA repair factor
01
Overview
PWWP domain-containing protein 2B (PWWP2B) is a nuclear chromatin-binding protein characterized by its PWWP domain, an approximately 70 amino acid motif mediating protein-protein and protein-DNA/histone interactions. It forms a variant NuRD complex that modulates histone acetylation at actively transcribed genes and affects transcription elongation via RNA polymerase II. PWWP2B also plays a crucial role in DNA double-strand break repair, being rapidly recruited to damage sites through interactions with UHRF1 and MRE11, facilitating homologous recombination and genome integrity. Mutations in the gene are recurrent in gastric adenocarcinoma and associated with poor outcomes, implicating PWWP2B in cancer biology and genome stability. The function of PWWP2B as a chromatin modifier and DNA repair factor highlights its relevance in transcriptional regulation, thermogenesis, and disease pathophysiology.
- Other names
- PWWP2BPWWP2BA432J24.1FLJ46823PP8607
02
Mechanism of action
Not applicable—no current drugs directly target PWWP2B
03
Biological functions
Chromatin remodelingTranscriptional regulation (positive regulation of transcription elongation by RNA polymerase II)Regulation of histone acetylationNegative regulation of brown adipocyte thermogenesisDNA double-strand break repair (homologous recombination promoter)Nuclear protein mobilization to DNA damage
04
Disease associations
Cancer (notably gastric adenocarcinoma, with frequent mutations and poorer prognosis)Sotos syndromeGenome instability contributing to cancer development
05
Safety considerations
None established; no therapeutic drug targeting PWWP2B is reported, but loss of function causes genome instability which could have implications for safety in future interventions
06
Biomarkers
Potential biomarker for poor prognosis in gastric cancer (mutation status correlates with survival)
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