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Apoptosis-associated Speck-like Protein Containing a CARD (ASC)
- Target
- ASC
- Molecular classification
- Adaptor protein
01
Overview
ASC (Apoptosis-associated Speck-like Protein Containing a CARD), encoded by the PYCARD gene, is a key adaptor protein involved in inflammasome assembly and the regulation of pyroptosis and apoptosis. It contains an N-terminal Pyrin Domain (PYD) and a C-terminal Caspase Recruitment Domain (CARD), which facilitate its interaction with upstream sensor proteins and downstream effectors like procaspase-1. ASC oligomerizes into specks or filaments, serving as a platform for caspase activation and cell death induction. Its expression and function are dysregulated in various diseases, including cancer, infections, and autoimmune disorders.
- Other names
- PYCARDPYD and CARD domain-containing proteinCaspase recruitment domain protein 5Target of methylation-induced silencing (TMS1)TMS1
02
Mechanism of action
Modulating inflammasome activity, modulating apoptosis
03
Biological functions
Inflammasome assemblyPyroptosis inductionApoptosis regulationCytokine productionInnate immune response
04
Disease associations
InflammationInfectionCancerAutoimmunityInflammatory Diseases
05
Safety considerations
Potential for off-target effects due to broad role in inflammation and apoptosisContext-dependent effects in cancer (tumor promotion vs. suppression)
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