Pygopus family PHD finger 1 (PYGO1)

Pygopus family PHD finger 1 (PYGO1) is a nuclear protein containing a plant homeodomain (PHD) zinc finger, acting as a transcription co-activator and chromatin modulator, and is a core component of the Wnt/β-catenin signaling complex[1][2][4][7]. It binds methylated histones and associates with transcriptional co-factors (such as BCL9/BCL9L), regulating gene expression during embryogenesis, development, and in cancer. PYGO1, along with its paralog PYGO2, plays a modulatory role in canonical Wnt signaling by linking nuclear β-catenin to chromatin regulation, affecting organ development (especially kidney and reproductive tissues) and certain malignancies[1][7]. No approved drugs are currently known to target PYGO1 directly, but its critical signaling role makes it a potential therapeutic target in Wnt-driven cancers and developmental disorders[7].

Other names

Pygopus homolog 1pygopus-like protein 1PYGO1Pygopus-like protein 1

null (not specified for drugs, as none are reported directly targeting the protein; mechanisms would likely involve inhibition of Wnt/β-catenin pathway co-activation if discovered)[1][2][7]