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Pyridoxal Kinase
- Molecular classification
- Enzyme, Kinase
01
Overview
Pyridoxal kinase (EC 2.7.1.35) is an essential enzyme that catalyzes the phosphorylation of vitamin B6 vitamers—pyridoxal (PL), pyridoxine (PN), and pyridoxamine (PM)—using ATP as a phosphate donor. This reaction produces their respective 5'-phosphate forms, most notably pyridoxal 5'-phosphate (PLP), which is the biologically active coenzyme form of vitamin B6. PLP acts as a cofactor for over 140 different enzymatic reactions in humans. Dysregulation or mutation of PDXK has been linked to neurological disorders, and overexpression has been associated with cancer cell proliferation.
02
Mechanism of action
Inhibition of pyridoxal kinase activity to reduce PLP production.
03
Biological functions
Vitamin B6 metabolismCofactor biosynthesisNeurotransmitter synthesisAmino acid metabolismGlycogen breakdownNucleic acid synthesisHeme biosynthesisLipid metabolismImmune regulation
04
Disease associations
Neurological disordersCancerVitamin B6 deficiency
05
Safety considerations
Potential neurotoxicity from excess free PLP.Potential side effects from modulating cellular metabolism
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