Pyridoxal phosphatase

Pyridoxal phosphatase is an enzyme that catalyzes the hydrolysis of pyridoxal 5′‑phosphate (PLP), the active form of vitamin B6, into pyridoxal and inorganic phosphate. It belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name for this enzyme is pyridoxal‑5′‑phosphate phosphohydrolase. It plays a crucial role in vitamin B6 metabolism by regulating cellular levels of PLP, which serves as a coenzyme in numerous enzymatic reactions essential for amino acid metabolism and other biosynthetic processes. Several alternative names are used for this enzyme, including PLP phosphatase and vitamin B6-phosphatase. Structural studies have revealed multiple solved structures for this class of enzymes[1]. There are no widely recognized drugs that directly target or inhibit pyridoxal phosphatase in clinical use or development.

Other names

Pyridoxal-5′-phosphate phosphohydrolaseVitamin B6 (pyridoxine) phosphatasePLP phosphataseVitamin B6-phosphate phosphatasePNP phosphatase