Pyrimidine nucleoside pool restoration

Pyrimidine nucleoside pool restoration describes therapeutic or physiological interventions aimed at correcting imbalances in intracellular pyrimidine nucleoside or nucleotide concentrations (e.g., dCTP, dTTP), which are critical for DNA replication, genome stability, and cell proliferation. Pool disequilibrium leads to replication stress and genomic instability, which are particularly deleterious in rapidly proliferating tissues and in cancer or certain genetic diseases (e.g., Bloom syndrome). Restoration typically involves modulating enzymes of pyrimidine synthesis or salvage pathways or supplying exogenous nucleosides to achieve balanced de novo and salvage nucleotide synthesis

Other names

Nucleotide pool restorationPyrimidine pool rebalancingPyrimidine nucleotide pool restoration

Enhancing or restoring nucleotide pool balance by modulating nucleotide biosynthesis, salvage, or recycling Preventing accumulation or depletion of specific nucleotide species Alleviating replication stress induced by imbalance