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Thiamine Diphosphate-Dependent Enzyme (ThDP-dependent enzyme)

Target: ThDP-dependent enzyme
Molecular classification: Enzyme, Lyase, Oxidoreductase, Transferase

Overview

Thiamine diphosphate-dependent enzymes (ThDP-dependent enzymes) are a diverse superfamily of proteins that require thiamine diphosphate as a cofactor. These enzymes catalyze various reactions, most notably the formation or cleavage of carbon-carbon bonds, and play essential roles in central metabolism. They are targets for herbicides, antibiotics, anticancer agents, and neuroprotective drugs. Examples include pyruvate decarboxylase, transketolase and DXPS.

Other names: Vitamin B1-dependent enzymeThDP enzymeTPP-dependent enzymeTransketolasePyruvate decarboxylase1-deoxy-D-xylulose 5-phosphate synthaseDXPS

Mechanism of action

Inhibition of enzymatic activity

Biological functions

CatalysisDecarboxylationTransketolationOxidation-reductionCarbon-carbon bond formationGlycolysisPentose phosphate pathwayAmino acid metabolismIsoprenoid biosynthesis

Disease associations

InfectionCancerNeurological disorders

Safety considerations

Off-target effects due to structural similarities with mammalian enzymes.Potential for drug resistance development in pathogens.

Interacting drugs

Thiamine analogs

5 more in the full profile.

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