Pyruvate dehydrogenase kinase 1 pseudogene 2 (PDK1P2)

PDK1 pseudogene 2 (PDK1P2) is a non-coding pseudogene related to Pyruvate dehydrogenase kinase 1 (PDK1). Pseudogenes are generally non-functional copies of ancestral genes that may be transcribed as RNA but do not code for functional proteins due to mutations, frameshifts, or premature stop codons[5]. PDK1P2 has sequence similarity to the functional PDK1 gene but lacks protein-coding capacity. Some recent research has identified PDK1P2 (also referred to as lncRNA-PDPK2P) as a long non-coding RNA capable of acting as a competitive endogenous RNA, thereby indirectly regulating PDK1 levels and, subsequently, cellular processes such as proliferation and apoptosis in cancers like hepatocellular carcinoma[1]. However, PDK1P2 itself is not a therapeutic drug target, receptor, enzyme, or signaling protein, but may have an ancillary regulatory function on its functional counterpart.[1][5] If your inquiry pertains to druggable or therapeutically relevant protein targets, the correct entry would be "Pyruvate dehydrogenase kinase 1 (PDK1)" rather than the pseudogene PDK1P2.

Other names

Pyruvate dehydrogenase kinase 1 pseudogene 2Pyruvate dehydrogenase kinase, isozyme 1 pseudogenePDPK2PlncRNA-PDPK2P