Pyruvate Kinase Liver and Red Blood Cell Isoform (None)

Pyruvate kinase is a key glycolytic enzyme that catalyzes the final step of glycolysis: the transfer of a phosphate group from phosphoenolpyruvate (PEP) to adenosine diphosphate (ADP), producing pyruvate and adenosine triphosphate (ATP). The liver and red blood cell isoforms—PKL and PKR—are both encoded by the PKLR gene. Mutations in the PKLR gene can cause pyruvate kinase deficiency—a common cause of hereditary nonspherocytic hemolytic anemia due to impaired ATP production in erythrocytes.

Catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to adenosine diphosphate (ADP), producing pyruvate and adenosine triphosphate (ATP).