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Pyruvate kinase muscle isoform 2 (PKM2)
- Target
- PKM2
- Molecular classification
- Enzyme, Kinase, Metabolic enzyme, Transcription factor coactivator
01
Overview
Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme catalyzing the final step of glycolysis. It is predominantly expressed in embryonic tissues, adult proliferating cells, tumor cells, and certain normal proliferating cell types. PKM2 exists in monomeric, dimeric, or tetrameric forms, with the tetrameric form being highly active. It plays crucial roles in cancer metabolism, inflammation, and immune regulation, making it an important therapeutic target.
- Other names
- Pyruvate kinase isozyme M2Tumor M2-PKPKMPK3
02
Mechanism of action
Inhibition of PKM2 activity, modulation of PKM2 oligomerization
03
Biological functions
GlycolysisATP productionCell proliferationAnabolic metabolismImmune regulationAngiogenesisInflammation regulation
04
Disease associations
CancerInflammationAutoimmune diseasesMetabolic disorders
05
Safety considerations
Potential for off-target effects due to PKM2's role in normal cell metabolismDevelopment of resistance to PKM2 inhibitorsCompensatory mechanisms that bypass PKM2 inhibition
06
Biomarkers
PKM2 expression levels in tumorsPKM2 serum levels
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