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Pyruvate Kinase R (PKR)

Target: PKR
Molecular classification: Enzyme

Overview

Pyruvate kinase R (PKR) is an isoform of the enzyme pyruvate kinase, which catalyzes the final, rate-limiting step of glycolysis: the conversion of phosphoenolpyruvate (PEP) and ADP to pyruvate and ATP. This reaction is crucial for cellular energy production, especially in tissues that rely heavily on glycolysis, most notably in red blood cells. PKR deficiency leads to impaired ATP generation in red blood cells, resulting in hemolytic anemia. It is predominantly expressed in erythrocytes.

Other names: PKLRPyruvate kinase R-type

Mechanism of action

Not applicable for current drugs, but potential mechanisms could involve allosteric modulation or inhibition.

Biological functions

GlycolysisATP production

Disease associations

Hemolytic anemia

Safety considerations

Potential for unintended effects on glycolysis in other tissues if targeted systemicallyDevelopment of resistance in deficient individuals is possible.

Biomarkers

PKR activity levels in red blood cells

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