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Qi regulation in traditional Chinese medicine (TCM) refers to the harmonization of the body's vital energy, Qi, believed to flow through meridians and influence health. TCM attributes illness to imbalances, deficiencies, or blockages of Qi, and seeks to restore balance through acupuncture, herbal medicine, qigong, tai chi, and lifestyle interventions[1][2][4][5][7]. Qi is not a defined physical substance or molecular entity, but rather a philosophical construct signifying the dynamic, transformative force underlying all biological and physiological activity[2][6]. Various types of Qi (e.g., Yuan Qi, Wei Qi, Ying Qi) are differentiated by their sources and functions. There is no scientific consensus or laboratory evidence supporting the existence of Qi as understood in TCM, nor any equivalent molecular target[3]. As such, "Qi regulation" lacks specificity and cannot be mapped to a druggable molecule, receptor, or target in conventional biomedical research.
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