Qi and Yin Deficiency Syndrome (QYDS)

Qi and Yin Deficiency Syndrome (QYDS) is a pathological pattern in Traditional Chinese Medicine (TCM) defined by the concurrent loss of 'Qi' (vital energy) and 'Yin' (moistening and cooling functions) (PMID: 30202319). It is a prevalent syndrome in chronic metabolic and cardiovascular diseases, notably Type 2 Diabetes Mellitus and Chronic Heart Failure (PMID: 28634510). Molecularly, QYDS is linked to mitochondrial impairment, oxidative stress, and dysregulation of the neuroendocrine-immune network (PMID: 31456804). Therapeutic approaches focus on 'tonifying Qi and nourishing Yin,' often utilizing the Shengmai formula (comprising Ginseng, Ophiopogon, and Schisandra) to improve cardiac function and glucose metabolism (PMID: 25535470). As a systemic syndrome rather than a single protein or receptor, it represents a holistic phenotype for multi-component drug interventions rather than a specific molecular target.

Other names

Deficiency of both Qi and YinQi-Yin deficiencyDual deficiency of Qi and YinQi-Yin Liang Xu

Therapeutic intervention aims to tonify Qi and nourish Yin to restore physiological homeostasis, improve mitochondrial function, and modulate the neuroendocrine-immune network (PMID: 25535470).