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Qi flow and blood circulation

Molecular classification
Other
01

Overview

"Qi flow and blood circulation" is a cornerstone of Traditional Chinese Medicine (TCM) theory, representing the dynamic movement of vital energy (qi) in conjunction with the circulatory function of blood. Qi is viewed as the vital force or life energy that animates the body and maintains physiological processes, whereas blood is regarded as its yin counterpart providing nourishment[1][3][4][5]. In TCM, optimal health requires balanced interaction and smooth flow of both qi and blood; stagnation or deficiency is thought to cause a spectrum of diseases, with therapeutic approaches such as acupuncture, herbal medicine, and qigong aimed at 'regulating qi' and 'promoting blood circulation'[1][2][4][7]. These concepts, and the interventions used to influence them, do not correspond to specific biological molecules, receptors, or druggable protein targets as conventionally defined in modern biomedical science, and the existence of qi as a physical entity has no scientific validation[4][5][7]. There is no canonical molecular abbreviation, family, or specific pharmacological or genetic biomarker, as "qi flow and blood circulation" is a broad, non-molecular diagnostic and therapeutic construct unique to TCM, not a molecular or receptor-level drug target.

Other names
Qi movementQi and blood flowQi and blood circulationQi stagnation and blood stasis
02

Mechanism of action

Conceptual regulation of qi and/or blood flow, presumed to address 'qi stagnation' or 'blood stasis' (TCM pathology); not molecularly defined[2][5][7]

03

Biological functions

Maintenance of energy balancePromotion of blood circulationHomeostasisGeneral support of organ function (as conceptualized in TCM)Other
04

Disease associations

Conceptualized in TCM as involved in cardiovascular disease, fatigue, metabolic disorders, depression (in TCM theory, not in biomedical taxonomy)[5][7]Other
05

Safety considerations

Lack of molecular specificityAbsence of established pharmacological mechanismRisk of misdiagnosis/misapplication when translated into biomedical contextsUse of multi-herb formulas may cause herb–drug interactions or adverse effectsOther
06

Interacting drugs

Xuefu Zhuyu decoction

2 more in the full profile.

07

Biomarkers

Serum ATP level, BDNF, serotonin (in some TCM research as proxies for efficacy in cardiovascular or depressive symptoms, not as direct biomarkers for 'qi')[7]

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