Qingfei Paidu Decoction target network (QFPDD target network)

The Qingfei Paidu Decoction (QFPDD) target network refers to a collection of 790 predicted protein targets identified through network pharmacology to explain the therapeutic effects of this Traditional Chinese Medicine (TCM) formula. QFPDD, composed of 21 herbs, was a primary treatment recommended for COVID-19 in China due to its ability to manage respiratory symptoms and systemic inflammation (Zhao et al., 2020, Pharmacological Research). The network includes critical inflammatory mediators like Tumor Necrosis Factor (TNF) and Interleukin-6 (IL-6), viral entry receptors such as Angiotensin-converting enzyme 2 (ACE2), and metabolic enzymes like the Cytochrome P450 (CYP) family (Yang et al., 2020, Traditional Medicine Research). By targeting these diverse proteins, the decoction is thought to inhibit viral replication while simultaneously preventing the cytokine storm associated with severe infections (Zhang et al., 2020, Journal of Ethnopharmacology). This multi-target profile reflects the holistic approach of TCM, though it presents challenges for standard drug development and safety monitoring, particularly regarding herb-drug interactions mediated by CYP enzymes. As this entry describes a large-scale interaction network rather than a single discrete molecule, it is classified as a target set or network model.

Other names

Qingfei detoxification soup targetsQFPDD 790-target networkQingfei Paidu Tang targetsPredicted targets of QFPDD

Synergistic multi-target modulation of the cytokine storm, inhibition of viral entry via ACE2, and regulation of metabolic pathways through CYP enzymes to restore physiological homeostasis.