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Target intelligence / Profile preview
Quiescin Sulfhydryl Oxidase 1 (QSOX1)
- Target
- QSOX1
- Molecular classification
- Enzyme, Oxidase
01
Overview
QSOX1 is an enzyme that catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to form disulfide bonds, with the concomitant reduction of molecular oxygen to hydrogen peroxide. It contains both an ERV family module and a thioredoxin domain. Its expression increases as fibroblasts exit the cell cycle into quiescence and it contributes to extracellular matrix assembly and normal cell-cell adhesion and migration. It is upregulated in certain cancers and has been implicated in sorafenib-induced ferroptosis in hepatocellular carcinoma.
- Other names
- Sulfhydryl oxidase 1Quiescin Q6 sulfhydryl oxidase 1Q6QSCN6thiol oxidase 1testis tissue sperm-binding protein Li 62n[6]
02
Mechanism of action
N/A
03
Biological functions
Disulfide bond formationProtein foldingCell-cell adhesionCell migrationExtracellular matrix assemblyRegulation of cell growth
04
Disease associations
Cancer
05
Safety considerations
Context-dependent role in cancer progression (can be associated with both poor and favorable outcomes)
06
Biomarkers
Overexpression in certain cancers (breast, pancreas, prostate) as a prognostic indicator
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