Quiescin sulfhydryl oxidase 2 (QSOX2)

Quiescin sulfhydryl oxidase 2 (QSOX2) is an enzyme belonging to the sulfhydryl oxidase family, encoded by the QSOX2 gene, and acts to catalyze the conversion of sulfhydryl groups into disulfide bonds in proteins, a critical step in oxidative protein folding. QSOX2 is secreted into the extracellular space and is periodically expressed throughout the cell cycle, peaking in the G1/S phase and regulated by the transcription factor E2F1. It promotes cell proliferation and survival and is essential for expression of cell division-associated genes and Wnt pathway activators (such as PRRX2 and β-catenin). In cancer, particularly non-small cell lung cancer and neuroblastoma, QSOX2 is overexpressed and associated with poor prognosis and disease progression; its knockdown inhibits proliferation and induces apoptosis in tumor cells. QSOX2 is highlighted as a potential biomarker for assessing tumor burden and response to treatment, but there are currently no specific drugs or therapeutic mechanisms targeting QSOX2 described in the available literature.

Other names

Sulfhydryl oxidase 2QSCN6L1SOXNDKFZp762A2013Neuroblastoma-derived sulfhydryl oxidaseQuiescin Q6-like protein 1thiol oxidase 2quiescin Q6 sulfhydryl oxidase 2quiescin Q6-like 1