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Target intelligence / Profile preview
Quinone Oxidoreductase (NQO)
- Target
- NQO
- Molecular classification
- Enzyme, Flavoprotein
01
Overview
Quinone oxidoreductases are a family of flavoprotein enzymes that catalyze the reduction of quinones to hydroquinones, using electron donors such as NADH or NADPH. These enzymes play crucial roles in cellular defense against oxidative stress and detoxification of xenobiotics. The most studied members in mammals are NAD(P)H:quinone oxidoreductase 1 (NQO1) and NQO2.
- Other names
- NAD(P)H:quinone oxidoreductaseNQO1NQO2
02
Mechanism of action
Inhibition of quinone reductase activity
03
Biological functions
Antioxidant DefenseDetoxificationRegulation of Cellular Proteins
04
Disease associations
CancerCardiovascular diseaseOxidative stress related diseases
05
Safety considerations
Chemoresistance mechanismsPotential for off-target effects
06
Interacting drugs
Dicoumarol
07
Biomarkers
NQO1 overexpression in cancer cells
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