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Target intelligence / Profile preview
Quinone oxidoreductase NQO1 (NQO1)
- Target
- NQO1
- Molecular classification
- Enzyme, Flavoprotein
01
Overview
Quinone oxidoreductase NQO1 is a cytoplasmic flavoprotein enzyme that plays a crucial role in cellular defense against oxidative stress and xenobiotic toxicity. It catalyzes the two-electron reduction of quinones to hydroquinones, preventing the formation of semiquinone radicals and reactive oxygen species (ROS). NQO1 is overexpressed in many cancers, and its inhibition can sensitize cancer cells to chemotherapy. Genetic polymorphisms in NQO1 can affect individual susceptibility to toxins and carcinogens.
- Other names
- DT-diaphoraseNAD(P)H quinone dehydrogenase 1NAD(P)H:quinone oxidoreductase
02
Mechanism of action
Inhibition of NQO1 activity
03
Biological functions
DetoxificationAntioxidant defenseStabilization of p53Redox cycling prevention
04
Disease associations
Cancer
05
Safety considerations
Potential for drug resistance due to NQO1 overexpression in cancerGenetic polymorphisms affecting NQO1 activity can influence drug response
06
Interacting drugs
Dicoumarol
07
Biomarkers
NQO1 expression level in cancer cells
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