Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Quinone Reductase 1 (NQO1)
- Target
- NQO1
- Molecular classification
- Enzyme, NAD(P)H dehydrogenase (quinone) family, Flavoprotein
01
Overview
Quinone reductase 1 (NQO1) is a cytosolic enzyme that catalyzes the two-electron reduction of quinones to hydroquinones, protecting cells from oxidative stress and electrophile toxicity. It plays roles in detoxification, antioxidant defense, drug metabolism, and stabilization of proteins and mRNA. NQO1 is often overexpressed in tumors and is a target for prodrug activation. Genetic polymorphisms affecting NQO1 activity can influence disease susceptibility and drug response.
02
Mechanism of action
Two-electron reduction of quinones to hydroquinones
03
Biological functions
DetoxificationAntioxidant defenseDrug metabolismProtein stabilizationmRNA binding
04
Disease associations
CancerTardive dyskinesiaColon adenocarcinomaCOPDMetabolic syndrome
05
Safety considerations
NQO1 overexpression in tumors can lead to increased activation of certain prodrugs, causing systemic toxicity.NQO1 deficiency due to genetic polymorphisms can increase vulnerability to oxidative damage or alter drug responses.
06
Interacting drugs
Mitomycin C
1 more in the full profile.
07
Biomarkers
NQO1 expression levels in tumorsNQO1 polymorphisms affecting activity
Beyond the preview
Go deeper on Quinone Reductase 1 (NQO1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Quinone Reductase 1 (NQO1).