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Target intelligence / Profile preview
R-spondin 3 (RSPO3)
- Target
- RSPO3
- Molecular classification
- Secreted protein, Growth factor, Wnt signaling modulator
01
Overview
R-spondin 3 (RSPO3) is a secreted protein and member of the R-spondin family that acts as a positive regulator of Wnt signaling pathways. It plays a critical role in embryonic development, stem cell maintenance, angiogenesis, and tumorigenesis. RSPO3 enhances Wnt/β-catenin signaling by binding to LGR4/5/6 receptors on stem/progenitor cells and modulating co-receptors such as LRP6. It also promotes VEGF expression and regulates vascular stability. Its role in cancer is context-dependent, acting as an oncogene in some cases and a tumor suppressor in others.
- Other names
- CRISTIN1PWTSRTHSD2Protein with TSP type-1 repeatRoof plate-specific spondin-3Thrombospondin type I domain containing 2
02
Mechanism of action
Potentiates Wnt/β-catenin signaling by binding to LGR4/5/6 receptors and modulating co-receptors such as LRP6, competing with antagonists like DKK1 for binding to LRP6/Kremen.
03
Biological functions
Wnt signaling modulationAngiogenesisStem cell maintenanceEmbryonic developmentCell proliferation
04
Disease associations
CancerColorectal cancerBreast cancerProstate cancerBladder cancer
05
Safety considerations
Context-dependent roles in cancer (oncogene or tumor promoter in some cancers, tumor suppressor in others)
06
Biomarkers
Prognostic marker in prostate cancer (higher levels associate with better relapse-free survival)
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