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Target intelligence / Profile preview
R-type Voltage-Gated Calcium Channel (Cav2.3)
- Target
- Cav2.3
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The Cav2.3/R-type voltage-gated calcium channel plays an essential role in neuronal excitability and synaptic transmission within key brain regions. Its unique pharmacological profile makes it both an interesting research target for understanding neurophysiology as well as a promising candidate for therapeutic intervention—particularly concerning certain types of epilepsies where its modulation may have clinical benefit.
- Other names
- R-type calcium channelα1E subunit
02
Mechanism of action
Voltage-dependent calcium channel blocker
03
Biological functions
Calcium ion influxNeurotransmitter releaseDendritic calcium signalingSynaptic transmission
04
Disease associations
EpilepsyAbsence epilepsyJuvenile myoclonic epilepsy (JME)Generalized convulsive tonic-clonic seizuresComplex-partial hippocampal seizures
05
Interacting drugs
Cadmium (Cd²⁺)
4 more in the full profile.
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