R3H domain-containing protein 4 (R3HDM4)

R3H domain-containing protein 4 (R3HDM4) is a protein encoded by the human R3HDM4 gene on chromosome 19[1][6][7]. It is predicted to enable nucleic acid binding and is localized to the nucleus[1][6]. The classical R3H domain is a conserved sequence motif present in proteins across eubacteria, plants, fungi, and animals, serving as a single-stranded DNA/RNA-binding domain typically found in combination with other functional domains[3][4]. While the R3H domain is structurally characterized in some proteins, the specific biological role of R3HDM4 in humans is not well-defined and there are no known disease associations, interacting drugs, or established use as a biomarker or therapeutic target[1][6][7]. The aliases “C19orf22” and “MGC16353” reflect previous nomenclature based on its chromosomal location and sequence identification[1]. R3HDM4 is primarily noted for its potential to bind nucleic acids through its R3H domain, but current literature does not support its involvement in pathophysiological processes or its recognition as a therapeutic target in clinical practice[1][6][7].

Other names

R3HDM4C19orf22MGC16353R3H domain-containing protein C19orf22