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Target intelligence / Profile preview
RAAG12
- Molecular classification
- Oligosaccharide, Carbohydrate Antigen
01
Overview
RAAG12 is a primate-restricted N-linked carbohydrate antigen present on multiple membrane-associated proteins. It is highly expressed in colon, gastric, and pancreatic adenocarcinomas, and recognized specifically by the monoclonal antibody RAV12, which is being developed as a therapeutic agent.
02
Mechanism of action
RAV12 acts as an inhibitor by binding specifically to the N-linked glycotope of RAAG12 expressed on cancer cells' membranes. This interaction can block receptor function (e.g., IGF1R), disrupt signaling pathways essential for tumor growth/survival, induce oncotic cell death directly through membrane perturbation or immune effector mechanisms such as ADCC/CDC.
03
Biological functions
Modulation of growth factor signalingCell death
04
Disease associations
Cancer
05
Safety considerations
Potential off-target effects due to expression on normal epithelial surfaces
06
Interacting drugs
RAV12
07
Biomarkers
RAAG12 expression level in tumor tissue
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