Rab-3A-interacting protein (RAB3IP)

Rab-3A-interacting protein (RAB3IP) is a guanyl-nucleotide exchange factor (GEF) that promotes the exchange of GDP for GTP on Rab proteins, activating their signaling function[6]. It binds to Rab3A and related small GTPases, catalyzing their transition from an inactive GDP-bound state to an active GTP-bound state, thereby regulating membrane trafficking, vesicle transport, and protein-protein interactions in various cellular processes[1][4][6]. RAB3IP is widely expressed in human tissues, participates in signal transduction and vesicle dynamics, and is associated with cellular compartmentalization, particularly in cytoplasm and cilia[1][3][4]. The molecule is implicated in some human diseases, notably cancer and potentially neurodegenerative conditions, through its regulatory role in vesicle transport and protein trafficking[2][4]. No directly interacting drugs, mechanism-of-action for such agents, specific biomarkers, or safety concerns are robustly described in the provided results.

Other names

RAB3IPRABIN3RABIN8Rabin-3Rabin8SSX2-interacting proteinrabin3rab-3A-interacting proteinSSX2 interacting proteinFLJ22548