RAB GTPase activating protein 1 (RAB-GAP1)

RAB GTPase activating protein 1 is a member of the TBC-domain (Tre-2, Bub2, Cdc16) family of GAPs that regulate Rab GTPases, key orchestrators of intracellular membrane trafficking. These proteins accelerate the intrinsic GTP hydrolysis on Rab GTPases, converting them from active (GTP-bound) to inactive (GDP-bound) states, thereby temporally and spatially terminating Rab signaling and ensuring proper membrane traffic and organelle identity[1][2][4]. Rab-GAPs, via their TBC domains, exhibit specificity for Rabs and are integral to maintaining the fidelity of cellular transport pathways; loss of function or mutation can lead to trafficking defects in model organisms[2]. These are not direct drug targets but are essential for the proper regulation of Rab-mediated transport mechanisms. If you require information on a particular human Rab-GAP (e.g., TBC1D1), clarification with an exact gene/protein name will yield more precise, structured information.

Other names

Rab-GAP1Gyp1 (in yeast)TBC-domain proteinRabGAPs (general family: TBC1D1, TBC1D2, etc.)

Not applicable; no drugs currently target Rab GAPs.