Rab-interacting lysosomal protein-like 2 (RILPL2)

Rab-interacting lysosomal protein-like 2 (RILPL2) is a member of the RILP family of Rab effectors, closely related to Rab-interacting lysosomal protein (RILP) and RILP-like protein 1. RILPL2 is up-regulated during differentiation of multiciliated cells and localizes dynamically to the primary cilium and centrosome. It plays a crucial role in regulating the protein content of the ciliary membrane, possibly by promoting removal of proteins from the primary cilium. Unlike RILP, RILPL2 does not regulate lysosomal morphology or trafficking, but it binds activated forms of several Rab proteins (notably Rab34, Rab36, Rab12)[1][2][3]. Depletion of RILPL2 causes abnormal accumulation of signaling proteins in the ciliary membrane and disrupts epithelial cell organization in three-dimensional culture, implicating it in processes central to cilia function and potentially in ciliopathies[1]. Note: There is no evidence that RILPL2 is a therapeutic target (such as a well-validated receptor, enzyme, or transporter for drugs), nor are there known interacting drugs, mechanisms of action for drug targeting, biomarkers, or specific safety concerns reported in the available scientific literature[1][2][3].

Other names

RILP-like protein 2RLP2MGC7036FLJ30380FLJ32372rab-interacting lysosomal protein-like 2p40phox-binding protein