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Target intelligence / Profile preview
Rab11 family-interacting protein 3 (RAB11FIP3)
- Target
- RAB11FIP3
- Molecular classification
- Other (Rab11 effector protein; not generally classified as receptor, enzyme, ion channel, etc.), Rab11-interacting protein, Endosomal trafficking adaptor, Cytoskeletal adaptor
01
Overview
Rab11 family-interacting protein 3 (RAB11FIP3) is a cellular adaptor protein involved in membrane trafficking and vesicle transport within cells. It acts as a downstream effector for Rab11 GTPase, regulating endocytic recycling, membrane delivery during cell division (cytokinesis), and intracellular ciliogenesis. RAB11FIP3 is critical for maintaining the integrity and function of the endosomal recycling compartment (ERC) and facilitates the movement of endosomes along microtubules by linking Rab11 to the dynein motor complex. RAB11FIP3 operates through direct interaction with Rab11A and forms complexes with cytoskeletal motor proteins and the exocyst, orchestrating the inward trafficking of vesicles for membrane recycling, division completion, and ciliary assembly. Its functional disruption leads to defects in cytokinesis, abscission, and cell proliferation, underlying its roles in diseases such as congenital muscular dystrophy, Brugada syndrome, and potential involvement in cancer cell motility. It is not classified as a receptor, enzyme, or transporter but rather functions as an adaptor protein in the Rab GTPase trafficking network.
- Other names
- Rab11 family-interacting protein 3RAB11FIP3ARFO1KIAA0665FIP3FIP3-Rab11Rab11-FIP3EferinArfophilin-1EF hands-containing Rab-interacting proteinMU-MB-17.148CART1cytoplasmic adaptor for RAR and TR
02
Biological functions
Membrane traffickingEndosomal recyclingCytokinesis (completion of cell division)Ciliogenesis (cilium formation)Organization of endosomal recycling compartment (ERC)Interaction with cytoskeletal motor proteins (dynein, kinesin, myosin)Intracellular vesicle targeting and fusion
03
Disease associations
Cancer (notably breast cancer cell motility)Muscular dystrophy (Congenital Muscular Dystrophy-Dystroglycanopathy Type A7)Cardiac arrhythmias (Brugada syndrome 5)Other (cell division defects)
04
Safety considerations
Targeting Rab11 family-interacting protein 3 could theoretically impact essential cellular functions such as cell division, membrane trafficking, and cilium formation, posing risks of cytotoxicity, impaired proliferation, or unwanted systemic effectsNo specific drug safety concerns or therapeutic challenges have been documented for direct pharmacologic targeting (as of current literature)
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